Ukungalali okuphindaphindiwe kanye nokuvuka kusenesikhathi, isiyezi esingachazeki kanye nokukhathala, induna eqhubekayo, kanye nezinkinga zokugaya ukudla ezishintshashintshayo… lezi zimpawu ezinganakwa kalula zingase zihlobane nokuvuvukala okungapheli. Ukuvuvukala okungapheli kwaziwa ngokuthi “umbulali othule,” okucashe emzimbeni isikhathi eside, kuqothula izicubu nezitho zomzimba buthule. Okwesabisa nakakhulu, kungasebenza “njengesisusa” sokuphindeka komdlavuza.
01. Ukuvuvukala Okungapheli
"I-catalyst" yokubuyela emuva komdlavuza
Ucwaningo oluqavile olushicilelwe kuyi-Proceedings of the National Academy of Sciences ngamathimba ocwaningo avela e-Chinese Academy of Sciences kanye naseMassachusetts Institute of Technology luqinisekisa ukuthi ukuvuvukala okungapheli kungavusa amangqamuzana omdlavuza angasebenzi ezindaweni ezikude, okubangela ukusabalala komdlavuza kanye nokuphindaphinda kwawo.
Abacwaningi, ngokusebenzisa izivivinyo ezenziwa kumagundane, bathole ukuthi amanye amangqamuzana omdlavuza webele asakazeka emaphashini angena “esimweni sokungalali,” angahlukanisi noma akhi izimila. Kodwa-ke, lapho ukuvuvukala kubangelwa emaphashini, lawa mangqamuzana omdlavuza “alele” ayavuswa ngempumelelo, aphinde athole ikhono lawo lokuhlukanisa, ukwanda, nokwakha izimila ezisakazeka.
02. Ukuvuvukala okungapheli
Kuyimbangela eyinhloko yazo zonke izifo.
Ngaphansi kwezimo ezivamile, ukuvuvukala kuyindlela yokuzivikela yomzimba ekulimaleni nasekuthelelekeni. Kodwa-ke, lapho izici ezifana nokucindezeleka okungapheli kanye nokungalali kahle kuvimbela lokhu kuzivikela ukuthi kunciphe ngesikhathi esifanele, kuholela ekuvuvukeni okungapheli okubangelwa uhlelo lokuzivikela olusebenza ngokweqile. Lokhu kuvuselela ukuvuvukala okuqhubekayo kudala umjikelezo omubi womonakalo kanye nokulungiswa kwezicubu zomzimba, ekugcineni kuholele ekungasebenzi kahle kwezitho zomzimba futhi kuhlinzeke indawo evundile yokukhula nokusabalala kwamangqamuzana omdlavuza.
Ngaphezu kwalokho, ukuvuvukala okungapheli kuhlotshaniswa kakhulu nokukhula kwezifo ezahlukahlukene: ohlelweni lwenhliziyo nemithambo yegazi, ukuvuvukala okungapheli kungalimaza i-endothelium yemithambo yegazi, kusheshise i-atherosclerosis, futhi kwandise ingozi yomfutho wegazi ophakeme, isifo senhliziyo, kanye nokuphazamiseka kwenhliziyo; ohlelweni lwe-metabolic, izici zokuvuvukala zingaphazamisa ukuzwela kwe-insulin, okubangela isifo sikashukela sohlobo 2; ngisho nezifo ezifana nesifo i-Alzheimer's kanye ne-rheumatoid arthritis kuye kwaqinisekiswa ukuthi zihlobene nokuvuvukala okungapheli.
03. Izinzuzo ezimbili kokukodwa, okuphelele nokuphelele
Ukwakha ukuzivikela okuphelele okulwa nokuvuvukala komzimba wonke
Ngakho-ke, ukuthuthukisa ukuvuvukala okungapheli kuyindlela yokuzivikela ebalulekile yokugcina impilo. Ngaphezu kokuvimbela okuyisisekelo ngendlela yokuphila enempilo, ukwelashwa kokukhanya okubomvu, okunendlela yayo yokusebenza eyingqayizivele kanye nezici eziphephile nezingenasihlaseli, kuye kwasetshenziswa kabanzi ekwelapheni izifo ezahlukahlukene zokuvuvukala nezibuhlungu, njengokulimala kwezicubu ezithambile, isifo samathambo, kanye namanxeba esikhumba, futhi kufinyelele imiphumela ebalulekile yokwelapha.
Ucwaningo olushicilelwe ku-*Chinese Journal of Pain Medicine* luqinisekisile ukuthi ukushiswa kwemisebe yokukhanya okubomvu kunganciphisa kakhulu amazinga e-inflammatory factor IL-1β kanye ne-pain-inducing mediator PGE2 endaweni yokulimala, okubonisa ngokusobala imiphumela yayo emibili yokulwa nokuvuvukala kanye ne-analgesic kanye nekhono layo lokunciphisa ngempumelelo izimpawu zokuvuvukala ezifana nokubomvu, ukuvuvukala, ubuhlungu, kanye nokusha.
Izifundo zemitholampilo emikhakheni eyahlukene zikhombisile ukuthi ukukhanya okubomvu, ngemva kokumuncwa kahle yi-mitochondria, kungathuthukisa ukwakheka kwe-ATP, kunikeze amandla okulungisa. Ukungena kwayo okunamandla kukhuthaza nokwanda kwemithambo yegazi ezicutshini ezijulile, kwandise ukuhlinzekwa komoya-mpilo futhi kusize ekususeni imikhiqizo yokuvuvukala, ngaleyo ndlela kusheshiswe ukuxazulula kwezimpendulo zokuvuvukala. Ngaphezu kwalokho, ukukhanya okubomvu kungakhuthaza ama-fibroblast, okuholela ekwandeni kwe-collagen fiber futhi kukhuthaze ukuphulukiswa kwamanxeba nezilonda.
I-capsule ye-Merican phototherapy, esekelwe ekwelashweni kokukhanya okubomvu, idlula imikhawulo yendabuko ngezinzuzo zayo eziyinhloko "zokumbozwa okuphelele kanye nokwelashwa okuphelele," okudala imiphumela ye-photobiological kuwo wonke umzimba. Lo mphumela ungena ujule ku-mitochondria, uthuthukisa ukusebenza kahle kokuzilungisa futhi uthuthukise ukuhlinzekwa komoya-mpilo. Lokhu, futhi, kuthuthukisa kancane kancane izinkinga zokuvuvukala ezivela ezicini eziningi, okuhlanganisa ukuvuselelwa kwamandla, ukususwa kwemfucuza, kanye nokulawulwa kwesignali. Ngaphezu kwalokho, ihlanganisa imithombo eminingi yokukhanya ukusiza imisebenzi yomzimba ukuthi ibuyele esimweni sokulinganisela kanye namandla ayo.
Izinzuzo ezimbili: Ifinyelela ukumbozwa okulinganayo kuwo wonke umzimba kanye nokungena kwamandla okuphelele, okuvumela ukukhanya okubomvu ukuthi kusebenze ngesikhathi esisodwa kuzo zonke izingxenye zomzimba, okuletha ukuthuthukiswa kwesistimu yonke.
• Amandla aphezulu: Ahlonyiswe ngokukhishwa kwamandla aphezulu, ahlinzeka ngempumelelo eqinile nezinzile, ehlose ngqo izidingo eziyinhloko njengokulwa nokuvuvukala nokulungisa.
• Indlela ebanzi: Ibhekana nomsuka wentuthuko iyonke, ifinyelele ukuthuthukiswa kwempilo okunezinhlangothi eziningi ngesikhathi esisodwa.
Okokugcina, nakuba ukuvuvukala okungapheli kuyimfihlo futhi kufinyelela kude, akusikho okungalawuleki. Ngokusekelwe endleleni yokuphila enempilo, kanye namasu okungenelela kwesayensi, singayinqoba ngempumelelo le mpi yesikhathi eside yokulwa nokuvuvukala. Kwangathi wonke umuntu angakhululeka ezinkingeni zokuvuvukala futhi amukele impilo enempilo!