U-Endre Mester, udokotela waseHungary, kanye nodokotela ohlinzayo, udunyiswa ngokuthola imiphumela yebhayoloji yama-laser anamandla aphansi, okwenzeka eminyakeni embalwa ngemva kokusungulwa kwe-laser ye-ruby ngo-1960 kanye nokusungulwa kwe-laser ye-helium-neon (HeNe) ngo-1961.
UMester wasungula i-Laser Research Center eSemmelweis Medical University eBudapest ngo-1974 futhi waqhubeka nokusebenza lapho impilo yakhe yonke. Izingane zakhe zaqhubeka nomsebenzi wakhe futhi zawungenisa e-United States.
Ngo-1987 izinkampani ezithengisa ama-laser zathi zingelapha ubuhlungu, zisheshise ukuphulukiswa kokulimala kwezemidlalo, nokunye okuningi, kodwa kwakunobufakazi obuncane balokhu ngaleso sikhathi.
Ekuqaleni uMester wayebiza le ndlela ngokuthi “i-laser biostimulation”, kodwa ngokushesha yaziwa ngokuthi “ukwelashwa nge-laser kwezinga eliphansi” noma “ukwelashwa ngokukhanya okubomvu”. Njengoba ama-diode akhipha ukukhanya ashintshwe yilabo abafunda le ndlela, yabe seyaziwa ngokuthi “ukwelashwa ngokukhanya kwezinga eliphansi”, futhi ukuze kuxazululwe ukudideka mayelana nencazelo eqondile “yezinga eliphansi”, kwavela igama elithi “photobiomodulation”.