I-Gout kanye ne-Hyperuricemia
Ihlobo elishisayo, i-braai yasolwandle, iziphuzo ezibandayo ezibandayo, umoya opholile ovunguzayo …… akuyona “indlela yokuphila” yakho, kodwa isikhathi eside, qaphela ukuthi i-uric acid iphezulu kakhulu, okubangela ukuhlaselwa yi-gout okukhulu!
UGu Bingjie, iphini likadokotela oyinhloko womnyango we-rheumatology kanye ne-immunology weSibhedlela Sokuqala saseNanjing, uthe ezinsukwini ezimbalwa ezedlule, cishe iziguli ezingu-20 ezine-hyperuricemia kanye ne-gout zibonwa nsuku zonke, ezingama-90% zazo zingabesilisa, kanti iminyaka yokuqala iyaqhubeka nokuba mincane.
Ngakho-ke i-gout yenzeka kanjani futhi kungani ivame kakhulu kwabesilisa?
I-Gout ihlobene namazinga e-uric acid egazini
I-Gout, isifo sokuvuvukala esibangelwa ukugcwala kwamakristalu e-urate emalungeni ngenxa yamazinga aphezulu e-uric acid, kanye ne-hyperuricemia kanye ne-gout yizimo ezahlukene zesifo esifanayo.
Ngaphansi kwezimo ezivamile, u-90% we-uric acid uzophinde umuncwe umzimba, kanti u-10% osele uzokhishwa emzimbeni ngesimo somchamo, ukujuluka, kanye nendle ukuze izinga le-uric acid yomzimba ligcine ibhalansi eguquguqukayo. Kodwa-ke, lapho ama-purines amaningi kakhulu edliwa ekukhishweni ngokweqile kwe-uric acid, noma i-metabolism ye-uric acid ingakwazi ukukhishwa, ibhalansi izophulwa, okuholela ekugcinweni kwe-uric acid egazini, futhi ngokugeleza kwegazi kuzo zonke izingxenye zomzimba, emalungeni ngokuhamba kwegazi okuhamba kancane, izinga lokushisa eliphansi lizobekwa ukuze kwakheke amakristalu e-urate, okuholela ekusabeleni kokuvuvukala, okubangela ubuhlungu obukhulu.
Ngaphansi kwezimo ezivamile, u-90% we-uric acid uzophinde umuncwe umzimba, kanti u-10% osele uzokhishwa emzimbeni ngesimo somchamo, ukujuluka, kanye nendle ukuze izinga le-uric acid yomzimba ligcine ibhalansi eguquguqukayo. Kodwa-ke, lapho ama-purines amaningi kakhulu edliwa ekukhishweni ngokweqile kwe-uric acid, noma i-metabolism ye-uric acid ingakwazi ukukhishwa, ibhalansi izophulwa, okuholela ekugcinweni kwe-uric acid egazini, futhi ngokugeleza kwegazi kuzo zonke izingxenye zomzimba, emalungeni ngokuhamba kwegazi okuhamba kancane, izinga lokushisa eliphansi, kuzobekwa amakristalu e-urate, okuholela ekusabeleni kokuvuvukala, okubangela ubuhlungu obukhulu.
Kungani i-gout “ithanda” amadoda ikakhulukazi?
Ngaphezu kwalokho, izifundo zikhombisile ukuthi ama-hormone, njengabaqondisi ababalulekile be-metabolic, adlala indima ekukhiqizweni nasekukhishweni kwe-uric acid, okuhlanganisa ama-hormone ocansi, i-adrenocorticotropic hormone, i-thyroid hormone, i-insulin, njalo njalo. Lapho uhlelo lwe-endocrine lungasebenzi kahle, ukukhishwa noma ukusebenza kwala ma-hormone kungathinteka, okuholela ekwandeni kwamazinga e-uric acid, okubangela ukuthuthukiswa kwe-gout.
Kukhona futhi umehluko ongokwemvelo emazingeni ama-hormone phakathi kwabesilisa nabesifazane, lapho ama-androgens eba khona kwabesilisa kanye nama-estrogen kwabesifazane. I-estrogen ingakhuthaza ukukhishwa kwe-uric acid futhi ivimbele ukwakheka kwe-urate. Ngakolunye uhlangothi, ama-Androgens avimbela ukukhishwa kwe-uric acid ezinso futhi anciphise ukusebenza kahle kwe-metabolic yezinso, okuholela emazingeni aphezulu e-uric acid emzimbeni, ngaleyo ndlela kusheshiswe ukwakheka nokufakwa kwamakristalu e-uric acid. Idatha ikhombisa ukuthi kubantu abaningi, ngaphezu kwama-95% e-gout kwenzeka kwabesilisa, ukwanda kwabesifazane kungaphansi kwama-5%, kanti isilinganiso samadoda kwabesifazane siseduze nama-20:1.
Ngingayinciphisa kanjani ingozi yami ye-gout?
Akukhona lokho kuphela, ukuvela kwe-gout noma i-hyperuricemia kuhlobene kakhulu nokudla okungenampilo kanye nemikhuba yokuphila. Ngakho-ke, ukuze unciphise ingozi ye-gout, ungayivimbela nsuku zonke ngokwenza okulandelayo:
- Lawula umlomo wakho: Gwema ukudla okune-purine eningi, ungadla ukudla okune-alkaline eningi ukuze uthuthukise ukuncibilika kwe-uric acid emchameni futhi wandise inani le-uric acid eliphumayo.
- Phuza amanzi engeziwe: Ehlobo, umzimba womuntu ujuluka kakhulu, futhi uma kungenjalo ngesikhathi esifanele, kuholela kalula ekugcwaleni kwegazi, futhi ukugcwala kwe-uric acid egazini nakho kuyakhuphuka ngokufanele, okubangela i-gout.
- Ukulawula Isisindo: Ukukhuluphala akusona nje isifo se-metabolic, kodwa futhi kuyisici esizimele esiyingozi sokuthuthukiswa kwe-hyperuricemia kanye ne-gout ngoba amaseli amafutha akhipha ama-purines amaningi, okwandisa amazinga e-uric acid.
- Nyakazisa imilenze yakho: Izifundo zakwamanye amazwe zikhombisile ukuthi ukuvivinya umzimba nsuku zonke nge-aerobic ephansi (njengokuhamba ngokushesha, ukugijima, ukubhukuda, njll.) imizuzu engama-30 kuya kwengama-60, izikhathi ezine kuya kwezinhlanu ngesonto, kunganciphisa ukwanda kwe-gout.
Ucwaningo Lukhombisa Ukukhanya Okubomvu Kungase Kunciphise Izimpawu Ze-Gout
Ngaphezu kokulondoloza indlela yokuphila enempilo, enkambisweni yokwelapha i-gout, amalunga avuvukile, kanye nobuhlungu kuba yinkinga eyinhloko yesiguli ekhathaza kakhulu, kunezincwadi eziningi zesayensi ezibonisa ukuthi iziguli ze-gout ekwelashweni kokukhanya okubomvu zingathuthukisa ukusebenza kwezicubu, zisheshise ukululama kwemizwa eyonakele, futhi zinciphise ngempumelelo isikhathi sokuvuvukala nobuhlungu ukuze kuncishiswe ubuhlungu bomzimba nobengqondo besiguli, futhi kukhuthazwe inqubo yokululama, futhi ocwaningweni lwakamuva lwezokwelapha lubonise ukuthi ama-88% eziguli ezine-gout ngemva kokwelashwa kokukhanya okubomvu ubuhlungu buthuthukisiwe kakhulu, futhi bafinyelela ngisho nomphumela wokukhululeka ngokuphelele kobuhlungu. Ocwaningweni lwakamuva lwezokwelapha, kuboniswe ukuthi ama-88% eziguli ze-gout abe nokuthuthuka okukhulu ebuhlungwini ngemva kokwelashwa kokukhanya okubomvu, futhi afinyelele ngisho nomphumela wokukhululeka ngokuphelele kobuhlungu.
Ukuqinisekiswa okuningi kwemitholampilo kuphinde kwaveza ukuthi ukukhanya okubomvu kungamuncwa ngumzimba kanye nokungena okunamandla, kungakhuthaza ukukhula kwama-axon ezinzwa angaphandle owonakele, ukuze ukwakheka kwama-nerve myelin sheaths kusheshise ukulungiswa nokuvuselelwa kwezinzwa ezingaphandle owonakele, ngesikhathi esifanayo, ukukhanya okubomvu kungenza izicubu zendawo ze-pentazocine zinciphe, futhi ngaleyo ndlela zidlale indima ye-analgesia, ekhuthaza ukukhululeka kobuhlungu.
I-MERICAN Health Cabin esekelwe ekwelashweni kokukhanya okubomvu ihlanganisa ububanzi obuhlukahlukene bamaza okukhanya ukuze ikhiqize imiphumela yebhayoloji esikhumbeni somzimba wonke, engathuthukisa ukusebenza kwezicubu kanye nesimo sokudla, ithuthukise i-phagocytosis kanye nokuvuleka kwemithambo yegazi, futhi ivimbele ngempumelelo ukuvezwa kwama-cytokines ahlobene nobuhlungu, okusiza ekumuncweni kwama-exudates okuvuvukala, inciphise ubuhlungu bamalunga esiguli, inciphise inkomba ye-uric acid egazini, futhi ikhuthaze ukuthuthukiswa kwezimpawu zomtholampilo kanye nokuvuselelwa kwamalunga.
Kulezi zinsuku, i-gout isibe “indawo yesine ephezulu” ngemva kwesifo sikashukela, umfutho wegazi ophakeme kanye ne-hyperlipidemia. Ngokusekelwe endleleni yokuphila yesayensi nenempilo, ehambisana nokwelashwa kokukhanya okubomvu, ingakwazi ukunciphisa izimpawu ezingakhululekile futhi ngaleyo ndlela ikhuthaze ngempumelelo inqubo yokululama.