Izinkinga ze-thyroid zigcwele emphakathini wanamuhla, zithinta bonke ubulili neminyaka ngamazinga ahlukahlukene.Ukuxilongwa mhlawumbe kugeja kaningi kunanoma yisiphi esinye isimo futhi ukwelashwa okuvamile/imiyalelo yezinkinga zegilo kusemuva kwamashumi eminyaka ekuqondeni kwesayensi lesi simo.
Umbuzo esizowuphendula kulesi sihloko uthi - Ingabe ukwelashwa okulula kungabamba iqhaza ekuvimbeleni nasekwelapheni izinkinga zegilo/i-metabolism ephansi?
Uma sibheka ngezincwadi zesayensi siyakubona lokhoukwelapha ukukhanyaUmthelela we-thyroid emsebenzini wegilo uye wacwaningwa izikhathi eziningi, kubantu (isb u-Höfling DB et al., 2013), amagundane (isb. Azevedo LH et al., 2005), onogwaja (isb. Weber JB et al., 2014), phakathi kwabanye.Ukuze uqonde ukuthi kunganiukwelapha ukukhanyakungase, noma kungabi, kube nesithakazelo kulaba bacwaningi, okokuqala kudingeka siqonde izinto eziyisisekelo.
Isingeniso
I-Hypothyroidism (indlala yegilo ephansi, indlala yegilo engasebenzi kahle) kufanele ibhekwe njengento ehlukahlukene wonke umuntu awela kuyo, esikhundleni sesimo esimnyama noma esimhlophe esiphathwa abantu abadala kuphela.Ngokungangabazeki noma ubani emphakathini wanamuhla unamazinga e-hormone egilo afanelekile (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.).Ukwengeza ekudidekeni, kunezimbangela nezimpawu ezigqagqene nezinye izinkinga eziningana ze-metabolic ezifana nesifo sikashukela, isifo senhliziyo, i-IBS, i-cholesterol ephezulu, ukucindezeleka kanye nokulahlekelwa izinwele (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).
Ukuba 'nemetabolism ehamba kancane' empeleni kufana ne-hypothyroidism, yingakho kuhambisana nezinye izinkinga emzimbeni.Itholakala kuphela njenge-clinical hypothyroidism uma ifinyelela iphuzu eliphansi.
Ngamafuphi, i-hypothyroidism yisimo sokukhiqizwa kwamandla aphansi kuwo wonke umzimba ngenxa yomsebenzi ophansi we-hormone yegilo.Izimbangela ezijwayelekile ziyinkimbinkimbi, kuhlanganise nokudla okuhlukahlukene kanye nezici zokuphila ezifana;ukucindezeleka, ufuzo, ukuguga, amafutha e-polyunsaturated, ukudla okunama-carbohydrate aphansi, ukudla okunekhalori ephansi, ukuswela ubuthongo, ukudakwa ngokweqile, ngisho nokuzivocavoca ngokweqile.Ezinye izici ezifana nokuhlinzwa kokukhishwa kwe-thyroid, ukudla okune-fluoride, izindlela zokwelapha ezihlukahlukene, nokunye kubangela i-hypothyroidism.
Ukwelashwa okukhanyayo okungenzeka kube usizo kubantu abaphansi be-thyroid?
Ukukhanya okubomvu ne-infrared (600-1000nm)kungase kube usizo kumetabolism emzimbeni emazingeni amaningana ahlukene.
1. Ezinye izifundo ziphethe ngokuthi ukusebenzisa ukukhanya okubomvu ngendlela efanele kungase kuthuthukise ukukhiqizwa kwamahomoni.(Höfling et al., 2010,2012,2013. Azevedo LH et al., 2005. Вера Александровна, 2010. Gopkalova, I. 2010.) Njenganoma yisiphi isicubu emzimbeni, indlala yegilo idinga amandla ukwenza yonke imisebenzi yayo. .Njengoba i-hormone yegilo iyingxenye esemqoka ekukhuthazeni ukukhiqizwa kwamandla, ungabona ukuthi ukuntula kwayo emangqamuzaneni egilo kunciphisa kanjani ukukhiqizwa kwehomoni yegilo - umjikelezo ononya wakudala.I-thyroid ephansi -> amandla aphansi -> i-thyroid ephansi -> njll.
2. Ukwelashwa okululauma isetshenziswa ngendlela efanele entanyeni ingase iphule lo mjikelezo ononya, ngombono ngokuthuthukisa ukutholakala kwamandla wendawo, ngaleyo ndlela ukwandisa ukukhiqizwa kwe-hormone ye-thyroid yemvelo nge-gland futhi.Nge-gland yegilo enempilo ebuyiselwe, inqwaba yemiphumela emihle eya phansi ivela, njengoba umzimba wonke ekugcineni uthola amandla owadingayo (Mendis-Handagama SM, 2005. Rajender S, 2011).I-hormone ye-steroid (i-testosterone, i-progesterone, njll.) iqala futhi - isimo sengqondo, i-libido namandla ayathuthukiswa, izinga lokushisa lomzimba liyakhuphuka futhi ngokuyisisekelo zonke izimpawu ze-metabolism ephansi ziyabuyiselwa emuva (Amy Warner et al., 2013) - ngisho nokubukeka komzimba kanye ukukhanga ocansini kuyanda.
3. Ngokuhambisana nezinzuzo zesistimu ezingaba khona ezivela ekuchayekeni kwegilo, ukusebenzisa ukukhanya noma kuphi emzimbeni kungase futhi kunikeze imiphumela yesistimu, ngegazi (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010).Nakuba amangqamuzana egazi abomvu engenayo i-mitochondria;ama-platelet egazi, amangqamuzana amhlophe egazi nezinye izinhlobo zamaseli akhona egazini aqukethe i-mitochondria.Lokhu kukodwa kuyacutshungulwa ukuze kubonwe ukuthi kungani futhi kunganciphisa kanjani ukuvuvukala kanye namazinga e-cortisol - i-hormone yokucindezeleka evimbela i-T4 -> ukusebenza kwe-T3 (Albertini et al., 2007).
4. Uma umuntu ubengafaka ilambu elibomvu ezindaweni ezithile zomzimba (njengobuchopho, isikhumba, amasende, amanxeba, njll.), abanye abacwaningi bacabanga ukuthi mhlawumbe kungase kunikeze amandla angaphezulu wendawo.Lokhu kuboniswa kangcono ngezifundo zokwelashwa okukhanyayo ezinkingeni zesikhumba, izilonda kanye nezifo, lapho ezifundweni ezehlukene isikhathi sokuphulukiswa singancishiswaukukhanya okubomvu noma kwe-infrared(J. Ty Hopkins et al., 2004. Avci et al., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009).Umphumela wendawo wokukhanya ungabonakala uhlukile kodwa uhambisana nomsebenzi wemvelo wehomoni yegilo.
Ithiyori evamile neyamukelwa ngokuvamile yomthelela oqondile wokwelashwa kokukhanya ihilela ukukhiqizwa kwamandla eselula.Imiphumela kuthiwa yenziwa ngokuyinhloko nge-photodissociating nitric oxide (NO) kusukela kuma-enzyme e-mitochondrial (cytochrome c oxidase, njll.).Ungacabanga ngo-CHA njengesimbangi esiyingozi kumoya-mpilo, kufana ne-carbon monoxide.CHA ngokuyisisekelo ivala ukukhiqizwa kwamandla kumaseli, kwakha indawo emosha kakhulu ngamandla, lapho umfula uphansi ekhuphula i-cortisol/ingcindezi.Isibani esibomvukucatshangelwa ukuthi kuvinjwe lobu buthi be-nitric oxide, kanye nomphumela wokucindezeleka, ngokuwususa ku-mitochondria.Ngale ndlela ukukhanya okubomvu kungacatshangwa 'njengokunganaki kokuvikela ingcindezi', kunokuba kukhuphule ngokushesha ukukhiqizwa kwamandla.Imane ivumela i-mitochondria yamaseli akho ukuthi isebenze kahle ngokunciphisa imiphumela edambisayo yokucindezeleka, ngendlela i-hormone yegilo kuphela engenzi ngayo.
Ngakho-ke nakuba i-hormone yegilo ithuthukisa ukubala kwe-mitochondria nokusebenza kahle, inkolelo-mbono ephathelene nokwelashwa okulula iwukuthi ingase ithuthukise futhi iqinisekise imiphumela yegilo ngokuvimbela ama-molecule ahlobene nokucindezeleka.Kungase kube nezinye izindlela ezimbalwa ezingaqondile lapho kokubili indlala yegilo nokukhanya okubomvu kunciphisa ingcindezi, kodwa ngeke singene kuzo lapha.
Izimpawu zezinga eliphansi le-metabolic/hypothyroidism
Izinga lokushaya kwenhliziyo eliphansi (ngaphansi kuka-75 bpm)
Izinga lokushisa lomzimba eliphansi, ngaphansi kuka-98°F/36.7°C
Uzizwa ubanda njalo (isb. izandla nezinyawo)
Isikhumba esomile noma yikuphi emzimbeni
Imicabango ye-Moody / ethukuthele
Ukuzwa ingcindezi / ukukhathazeka
Inkungu yobuchopho, ikhanda
Izinwele/izinzipho ezikhula kancane
Izinkinga zamathumbu (ukuqunjelwa, ama-crohns, i-IBS, i-SIBO, ukuqunjelwa, isilungulela, njll.)
Ukuchama njalo
I-low/no libido (kanye/noma ukumiswa okubuthakathaka / ukugcotshwa okungekuhle kwesitho sangasese sowesifazane)
Ukuba sengozini kwemvubelo/candida
Umjikelezo wokuya esikhathini ongahambisani, osindayo, obuhlungu
Ukungabi nabantwana
Izinwele eziwohlokayo/ezincipha ngokushesha.Amashiya azacile
Ukulala okubi
Lusebenza kanjani uhlelo lwe-thyroid?
I-hormone yegilo iqala ukukhiqizwa endlaleni yegilo (etholakala entanyeni) ngokuvamile i-T4, bese ihamba ngegazi iye esibindini nakwezinye izicubu, lapho iguqulwa ibe ifomu elisebenza kakhulu - i-T3.Lolu hlobo olusebenzayo lwe-hormone yegilo bese luhambela kuwo wonke amangqamuzana omzimba, lusebenza ngaphakathi kwamaseli ukuthuthukisa ukukhiqizwa kwamandla kwamaselula.Ngakho indlala yegilo -> isibindi -> wonke amaseli.
Yini evamise ukungahambi kahle kule nqubo yokukhiqiza?Ochungechungeni lomsebenzi we-hormone yegilo, noma yiliphi iphuzu lingadala inkinga:
1. Indlala yegilo ngokwayo ayikwazi ukukhiqiza amahomoni anele.Lokhu kungase kube ngenxa yokuntuleka kwe-iodine ekudleni, ukweqisa kwamafutha e-polyunsaturated fatty acids (PUFA) noma ama-goitrogens ekudleni, ukuhlinzwa kwangaphambilini kwegilo, lokho okubizwa ngokuthi 'i-autoimmune' isimo sikaHashimoto, njll.
2. Isibindi asikwazanga 'ukuvula' amahomoni (T4 -> T3), ngenxa yokuntuleka kweglucose/glycogen, ukweqisa kwe-cortisol, ukulimala kwesibindi ngenxa yokukhuluphala ngokweqile, utshwala, izidakamizwa kanye nezifo, ukugcwala kwe-iron, njll.
3. Amaseli angase awamunce amahomoni atholakalayo.Ukumuncwa kwamaseli kwehomoni yegilo esebenzayo kuvame ukwehlela ezicini zokudla.Amafutha e-Polyunsaturated asuka ekudleni (noma emafutheni agciniwe akhululwa ngesikhathi sokuncipha) empeleni avimbela i-hormone yegilo ukuthi ingangeni kumaseli.I-glucose, noma ushukela ngokujwayelekile (i-fructose, i-sucrose, i-lactose, i-glycogen, njll.), ibalulekile kukho kokubili ukumuncwa nokusetshenziswa kwe-hormone yegilo esebenzayo ngamaseli.
I-hormone ye-thyroid esitokisini
Uma sicabanga ukuthi asikho isithiyo esikhona sokukhiqizwa kwehomoni yegilo, futhi ingafinyelela kumaseli, yenza ngokuqondile nangokungaqondile inqubo yokuphefumula emangqamuzaneni - okuholela ku-oxidation ephelele ye-glucose (i-carbon dioxide).Ngaphandle kwe-hormone yegilo eyanele 'yokuqaqa' amaprotheni e-mitochondrial, inqubo yokuphefumula ayikwazi ukuqeda futhi ngokuvamile iholela ku-lactic acid kunomkhiqizo wokugcina we-carbon dioxide.
I-hormone yegilo isebenza kuzo zombili i-mitochondria kanye ne-nucleus yamaseli, okubangela imiphumela yesikhashana neyesikhathi eside ethuthukisa i-oxidative metabolism.Ku-nucleus, i-T3 kucatshangwa ukuthi ithonya ukubonakaliswa kwezakhi zofuzo ezithile, okuholela ku-mitochondriogenesis, okusho ukuthi i-mitochondria eyengeziwe/entsha.Ku-mitochondria esivele ikhona, isebenzisa umphumela oqondile wokuthuthukisa amandla nge-cytochrome oxidase, kanye nokuphefumula okungahlangani okuvela ekukhiqizeni i-ATP.
Lokhu kusho ukuthi i-glucose ingaphushwa phansi endleleni yokuphefumula ngaphandle kokuthi kudingeke ukuthi ikhiqize i-ATP.Nakuba lokhu kungase kubonakale kuwukumosha, kwandisa inani le-carbon dioxide enenzuzo, futhi kumise ukunqwabelana kweglucose njenge-lactic acid.Lokhu kungabonakala ngokuseduze kubantu abanesifo sikashukela, abavame ukuthola amazinga aphezulu e-lactic acid okuholela esimweni esibizwa ngokuthi i-lactic acidosis.Abantu abaningi be-hypothyroid baze bakhiqize i-lactic acid ebalulekile ekuphumuleni.Ihomoni yegilo idlala indima eqondile ekudambiseni lesi simo esiyingozi.
Ihomoni yegilo inomunye umsebenzi emzimbeni, ihlangana novithamini A kanye ne-cholesterol ukuze kwakhiwe i-pregnenolone - isandulela sawo wonke amahomoni e-steroid.Lokhu kusho ukuthi amazinga aphansi egilo aphumela emazingeni aphansi e-progesterone, i-testosterone, njll. Amazinga aphansi kasawoti we-bile nawo azokwenzeka, ngaleyo ndlela aphazamise ukugaya.I-hormone yegilo mhlawumbe i-hormone ebaluleke kakhulu emzimbeni, okuthiwa ilawula yonke imisebenzi ebalulekile nemizwa yokuphila kahle.
Isifinyezo
Ihomoni yegilo ibhekwa ngabanye 'njengehomoni eyinhloko' yomzimba futhi ukukhiqizwa kuncike kakhulu endlaleni yegilo nesibindi.
I-hormone yegilo esebenzayo ivuselela ukukhiqizwa kwamandla e-mitochondrial, ukwakheka kwe-mitochondria eyengeziwe, namahomoni e-steroid.
I-Hypothyroidism yisimo samandla amancane weselula anezimpawu eziningi.
Izimbangela ze-thyroid ephansi ziyinkimbinkimbi, eziphathelene nokudla kanye nendlela yokuphila.
Ukudla okune-carb ephansi kanye nokuqukethwe okuphezulu kwe-PUFA ekudleni yizigebengu eziyinhloko, kanye nokucindezeleka.
I-thyroidukwelapha ukukhanya?
Njengoba indlala yegilo itholakala ngaphansi kwesikhumba namafutha entamo, eduze ne-infrared kuwuhlobo lokukhanya olufundwa kakhulu lokwelashwa kwegilo.Lokhu kunengqondo njengoba ingena kakhulu kunokubomvu okubonakalayo (Kolari, 1985; Kolarova et al., 1999; Enwemeka, 2003, Bjordal JM et al., 2003).Kodwa-ke, okubomvu njenge-wavelength ephansi njenge-630nm iye yafundelwa i-thyroid (Morcos N et al., 2015), njengoba iyindlala engaphezulu.
Imihlahlandlela elandelayo ivame ukulandelwa ezifundweni:
Ama-LED/ama-laser angabonakaliku-700-910nm ububanzi.
100mW/cm² noma ukuminyana kwamandla okungcono
Le mihlahlandlela isekelwe kumaza amaza asebenzayo ezifundweni ezishiwo ngenhla, kanye nezifundo zokungena kwezicubu nazo ezishiwo ngenhla.Ezinye zezinto ezithinta ukungena zihlanganisa;ukushaya kwenhliziyo, amandla, ukuqina, ukuthintana kwezicubu, i-polarization kanye nokuhambisana.Isikhathi sokufaka isicelo singancishiswa uma ezinye izici zithuthukiswa.
Ngamandla afanele, izibani ze-infrared ze-LED zingase zibe nomthelela kuyo yonke indlala yegilo, ngaphambili kuya emuva.Amaza okukhanya abomvu abonakalayo entanyeni azophinde anikeze izinzuzo, nakuba idivayisi enamandla izodingeka.Lokhu kungenxa yokuthi okubomvu okubonakalayo akungeneli kangako njengoba sekushiwo kakade.Njengesilinganiso esinzima, ama-LED abomvu angu-90w+ (620-700nm) kufanele anikeze izinzuzo ezinhle.
Ezinye izinhlobo zeubuchwepheshe bokwelapha okukhanyayonjengama-lasers asezingeni eliphansi alungile, uma ukwazi ukuwakhokhela.Ama-Lasers afundwa kaningi ezincwadini kunama-LED, nokho ukukhanya kwe-LED ngokuvamile kubhekwa njengokulinganayo ngomphumela (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Amalambu okushisa, ama-incandescent kanye nama-saunas e-infrared awasebenziseki ekuthuthukiseni izinga le-metabolic / hypothyroidism.Lokhu kungenxa ye-engeli ye-beam ebanzi, ukushisa okudlulele/ukungasebenzi kanye nokumoshakala kwe-spectrum.
Umugqa Ongezansi
Ukukhanya okubomvu noma kwe-infraredkusuka emthonjeni we-LED (600-950nm) ifundelwa indlala yegilo.
Amazinga e-hormone yegilo ayabhekwa futhi akalwe kulo lonke ucwaningo.
Uhlelo lwe-thyroid luyinkimbinkimbi.Ukudla kanye nendlela yokuphila nakho kufanele kubhekwe.
I-LED light therapy noma i-LLLT ifundwe kahle futhi iqinisekisa ukuphepha okuphezulu.Ama-LED e-infrared (700-950nm) athandwa kulo mkhakha, okubomvu okubonakalayo kulungile futhi.
Isikhathi sokuthumela: Sep-26-2022