I-Rosacea yisimo esibonakala ngokubomvu nokuvuvukala kobuso.Kuthinta cishe u-5% wabantu bomhlaba, futhi nakuba izimbangela zaziwa, azaziwa kakhulu.Kubhekwa njengesimo sesikhumba sesikhathi eside, futhi ngokuvamile sithinta abesifazane base-Europe/Caucasia abaneminyaka engaphezu kwengama-30. Kunezinhlobo ezincane ze-rosacea futhi zingathinta noma ubani.
Ukwelashwa kokukhanya okubomvu kufundwa kahle ezintweni ezifana nokuphulukiswa kwesikhumba, ukuvuvukala ngokuvamile, i-collagen esikhumbeni, nezimo zesikhumba ezihlobene ezihlukahlukene ezifana nezinduna.Ngokwemvelo intshisekelo ikhulile ekusebenziseni ukukhanya okubomvu kwe-rosacea.Kulesi sihloko sizobheka ukuthi ukwelashwa kokukhanya okubomvu (okubuye kwaziwe ngokuthi i-photobiomodulation, ukwelashwa kwe-LED, ukwelapha nge-laser, i-cold laser, i-light therapy, i-LLLT, njll.) kungasiza yini ukwelapha i-rosacea.
Izinhlobo zeRosacea
Wonke umuntu one-rosacea unezimpawu ezihluke kancane futhi ezihlukile.Nakuba i-rosacea ijwayele ukuhlotshaniswa nokubabomvu kobuso ekhaleni nasezihlathini, kunezinye izimpawu ezihlukahlukene ezingahle zihlukaniswe futhi zihlukaniswe zibe 'ama-subtypes' e-rosacea:
I-Subtype 1, ebizwa ngokuthi 'i-Erythematotelangiectatic Rosacea' (ETR), iyi-rosacea ecatshangwayo eveza ububomvu bobuso, ukuvuvukala kwesikhumba, imithambo yegazi eduze kwendawo kanye nezikhathi zokushaywa umoya.I-Erythema ivela egameni lesiGreki elithi erythros, elisho okubomvu - futhi libhekisela esikhumbeni esibomvu.
I-Subtype 2, I-Acne rosacea (igama lesayensi - i-papulopustular), i-rosacea lapho isikhumba esibomvu sihlanganiswa nokuqubuka okufana nezinduna noma okungapheli (ama-pustules nama-papules, hhayi amakhanda amnyama).Lolu hlobo lungabangela umuzwa ovuthayo noma wokuluma.
I-Subtype 3, i-AKA phymatous rosacea noma i-rhinophyma, iwuhlobo olungavamile lwe-rosacea futhi ihilela izingxenye zobuso eziya ziba mkhulu nakakhulu - ngokuvamile ikhala (ikhala lamazambane).Ivame kakhulu emadodeni amadala futhi ngokuvamile iqala njengolunye uhlobo oluncane lwe-rosacea.
I-Subtype 4 i-rosacea yeso, noma i-ocular rosacea, futhi ihilela amehlo anegazi, amehlo agcwele amanzi, umuzwa wento ethile esweni, ukuvutha, ukulunywa kanye noqweqwe.
Ukwazi ngama-subtypes e-rosacea kubalulekile ekunqumeni ukuthi unayo ngempela yini.Uma kungekho okwenziwa ukubhekana ne-rosacea, ivame ukuba yimbi kakhulu ngokuhamba kwesikhathi.Ngenhlanhla, ukusebenza kokwelashwa kokukhanya okubomvu ekwelapheni i-rosacea akushintshi ne-subtype.Okusho ukuthi iphrothokholi efanayo yokwelapha ukukhanya okubomvu izosebenza kuwo wonke ama-subtypes.Kungani?Ake sibheke izimbangela ze-rosacea.
Imbangela Yangempela yeRosacea
(...futhi kungani ukwelashwa okulula kungasiza)
Emashumini ambalwa eminyaka adlule, i-rosacea ekuqaleni yayikholelwa ukuthi iwumphumela wokutheleleka ngebhaktheriya.Njengoba ama-antibiotics (kuhlanganise ne-tetracycline) asebenza ngezinga elithile ukulawula izimpawu, kwabonakala kuwumbono omuhle….kodwa ngokushesha kwatholakala ukuthi awekho amagciwane ahilelekile.
Iningi lodokotela nochwepheshe be-rosacea kulezi zinsuku bazokutshela ukuthi i-rosacea iyindida futhi akekho othole imbangela.Abanye bazokhomba ku-Demodex mites njengembangela, kodwa cishe wonke umuntu unalezi futhi akuwona wonke umuntu one-rosacea.
Ngemva kwalokho bazobala 'izibangeli' ezihlukahlukene esikhundleni sembangela, noma benze iziphakamiso zokuthi ufuzo olungashiwongo kanye nezici zemvelo ziyimbangela.Nakuba izici zofuzo noma ze-epigenetic zingase zenze umuntu othile athole i-rosacea (ehlobene nomunye umuntu), azinqumi - aziyona imbangela.
Izici ezihlukahlukene zinomthelela ngempela ebukhulwini bezimpawu ze-rosacea (i-caffeine, izinongo, ukudla okuthile, isimo sezulu esibandayo/ esishisayo, ukucindezeleka, utshwala, njll.), kodwa nazo aziyona imbangela.
Pho kuyini?
Izinkomba zembangela
Umkhondo wokuqala wembangela uwukuthi i-rosacea ivamise ukukhula ngemva kweminyaka engu-30. Lena iminyaka lapho izimpawu zokuqala zokuguga zibonakala khona.Abantu abaningi bazoqaphela izinwele zabo zokuqala ezimpunga kanye nesikhumba sokuqala esincane esishwabene kule minyaka.
Omunye umkhondo iqiniso lokuthi ama-antibiotics ayasiza ekulawuleni izimpawu - nakuba kungekho ukutheleleka kwangempela (ukusikisela: ama-antibiotic angaba nemiphumela yesikhashana eqeda ukuvuvukala).
Ukugeleza kwegazi esikhumbeni esihlaselwe yi-rosacea kuphakeme izikhathi ezi-3 kuya kwezi-4 kunesikhumba esivamile.Lo mphumela we-hyperemia uyenzeka lapho izicubu namaseli engakwazi ukukhipha umoya-mpilo egazini.
Siyazi ukuthi i-rosacea ayiyona nje indaba yezimonyo, kodwa ihilela izinguquko ezibalulekile zokukhula kwe-fibrotic esikhumbeni (yingakho ikhala lamazambane kuhlobo olungaphansi 3) kanye nokukhula kwemithambo yegazi okuhlaselayo (okungalokho imithambo/ukushaywa).Uma lezi zimpawu ezifanayo zenzeka kwenye indawo emzimbeni (isb. i-uterine fibroids) zidinga uphenyo olubalulekile, kodwa esikhumbeni zibhekwa njengezindaba zezimonyo okufanele 'zilawule' 'ngokugwema izinto ezibangisayo', futhi kamuva nokuhlinzwa ukuze kukhishwe isikhumba esishubile. .
I-Rosacea iyinkinga ebalulekile ngoba imbangela eyinhloko izinqubo ze-physiological ezijulile emzimbeni.Isimo sokuphila esiholela kulezi zinguquko zesikhumba asithinti isikhumba kuphela - sithinta nawo wonke umzimba wangaphakathi.
Ukuguquguquka, imithambo yegazi ekhulayo/ehlaselayo kanye nokuqina kwesikhumba kungabonwa kalula e-rosacea, ngoba kubonakala esikhumbeni - ebusweni bomzimba.Ngandlela thize, kuyisibusiso ukuthola izimpawu ze-rosacea, ngoba kukubonisa ukuthi kukhona okungahambi kahle ngaphakathi.Ukulahleka kwezinwele zephethini yabesilisa kuyinto efanayo ngoba kukhomba ukungasebenzi kahle kwama-hormone.
Ukukhubazeka kwe-Mitochondrial
Konke ukubhekwa kanye nezilinganiso eziphathelene ne-rosacea kukhomba izinkinga ze-mitochondrial njengembangela eyinhloko ye-rosacea.
I-Mitochondria ayikwazi ukusebenzisa umoya-mpilo ngendlela efanele lapho ilimele.Ukungakwazi ukusebenzisa umoya-mpilo kwandisa ukugeleza kwegazi esicutshini.
I-Mitochondria ikhiqiza i-lactic acid lapho ingakwazi ukuthola nokusebenzisa umoya-mpilo, okuholela ekuvalweni kwe-vasodilation ngokushesha kanye nokukhula kwama-fibroblasts.Uma le nkinga iqhubeka isikhathi eside, imithambo yegazi emisha iqala ukukhula.
Izici ezihlukahlukene zama-hormone nezemvelo zingaba nomthelela ekusebenzeni kabi kwe-mitochondrial, kodwa esimweni sokwelapha ukukhanya okubomvu, umthelela obaluleke kakhulu uvela ku-molecule ebizwa ngokuthi i-Nitric Oxide.
I-Red Light Therapy ne-Rosacea
Ithiyori eyinhloko echaza imiphumela yokwelapha ukukhanya isuselwe ku-molecule ebizwa nge-Nitric Oxide (NO).
Lena i-molecule engaba nemiphumela ehlukahlukene emzimbeni, njengokuvimbela ukukhiqizwa kwamandla, i-vasodilation / ukunwetshwa kwemithambo yegazi, njalonjalo.Esikuthakasela kakhulu ekwelapheni okukhanyayo ukuthi le CHA ibophezela endaweni ebalulekile ochungechungeni lwakho lwezokuthutha lwe-electron emitochondrial, imise ukuhamba kwamandla.
Ivimba izigaba zokugcina zokusabela kokuphefumula, ngakho-ke ikuyekisa ukuthola ingxenye enkulu yamandla (i-ATP) nanoma iyiphi i-carbon dioxide evela ku-glucose/oksijeni.Ngakho-ke lapho abantu benezilinganiso eziphansi ze-metabolic eziphansi unomphela njengoba bekhula noma bebhekana nezikhathi zokucindezeleka/indlala, le CHA ivamise ukuba nesibopho.Kunengqondo uma ucabanga ngakho, emvelweni noma ekusindeni, udinga indlela yokwehlisa izinga lakho lokugayeka kokudla ngesikhathi sokutholakala okuphansi kokudla/ikhalori.Akuwenzi umqondo omkhulu ezweni lanamuhla lapho AKUKHO amazinga angathonywa izinhlobo ezithile zama-amino acid ekudleni, ukungcoliswa komoya, isikhunta, ezinye izici zokudla, ukukhanya okwenziwayo, njll. Ukuntuleka kwe-carbon dioxide emzimbeni wethu nakho. inyusa ukuvuvukala.
Ukwelashwa okukhanyayo kwandisa ukukhiqizwa kokubili kwamandla (ATP) kanye ne-carbon dioxide (CO2).I-CO2 yona ivimbela ama-cytokines ahlukahlukene abangela ukuvuvukala nama-prostaglandin.Ngakho-ke ukwelashwa okulula kunciphisa inani lokuvuvukala emzimbeni/indawo.
Nge-rosacea into esemqoka ethathwayo ukuthi ukwelapha okulula kuzonciphisa ukuvuvukala nobubomvu endaweni, futhi kuxazulule inkinga yokusetshenziswa komoyampilo okuphansi (okubangele ukukhula komkhumbi wegazi nokukhula kwe-fibroblast).
Isifinyezo
Kunezinhlobo ezingaphansi ezihlukahlukene kanye nokubonakaliswa kwe-rosacea
I-Rosacea iwuphawu lokuguga, njengemibimbi nezinwele ezimpunga
Umsuka we-rosacea unciphisa ukusebenza kwe-mitochondrial kumaseli
Ukwelashwa kokukhanya okubomvu kubuyisela i-mitochondria futhi kunciphisa ukuvuvukala, kuvimbele i-rosacea
Isikhathi sokuthumela: Sep-30-2022