Isifo i-Alzheimer's, isifo esiqhubekayo sokuwohloka kwemizwa, sibonakala ngezimpawu ezifana nokulahlekelwa yinkumbulo, i-aphasia, i-agnosia, kanye nokusebenza kabi kokusebenza. Ngokwesiko, iziguli bezithembele emithini yokwelapha izimpawu. Kodwa-ke, ngenxa yokulinganiselwa kanye nemiphumela emibi engaba khona yale mithi, abacwaningi bagxile ekwelashweni nge-phototherapy okungangenisi umthelela, bafinyelela impumelelo ebalulekile eminyakeni yamuva.
Muva nje, ithimba eliholwa nguSolwazi uZhou Feifan wase-Biomedical Engineering College yaseHainan University lithole ukuthi ukwelashwa nge-transcranial phototherapy okungathintani nodokotela kunganciphisa izimpawu ze-pathological futhi kuthuthukise amakhono okuqonda emagundwini asebekhulile kanye nalawo ahlushwa yi-Alzheimer's. Lokhu okutholakele okusha, okushicilelwe kumagazini i-Nature Communications, kunikeza isu elithembisayo lokuphatha izifo ze-neurodegenerative.
Ukuqonda I-Alzheimer's Disease Pathology
Imbangela eqondile ye-Alzheimer's ayikacaci kahle, kodwa ibonakala ngokuqongelelana kwamaprotheni e-beta-amyloid okungavamile kanye nokuxinana kwe-neurofibrillary, okuholela ekungasebenzi kahle kwe-neuronal kanye nokwehla kwengqondo. Ubuchopho, njengesitho esisebenza kakhulu emzimbeni, bukhiqiza imfucuza ebalulekile ye-metabolic ngesikhathi somsebenzi we-neural. Ukuqongelela ngokweqile kwale mfucuza kungalimaza ama-neurons, kudingeke ukususwa okuphumelelayo ngohlelo lwe-lymphatic.
Imithambo ye-meningeal lymphatic, ebalulekile ekukhipheni amanzi ohlelweni lwezinzwa oluphakathi, idlala indima ebalulekile ekususeni amaprotheni anobuthi e-beta-amyloid, imfucuza ye-metabolic, kanye nokulawula ukusebenza komzimba, okwenza kube yinto efanelekile yokwelashwa.
Umthelela we-Phototherapy ku-Alzheimer's
Ithimba likaProfesa Zhou lisebenzise i-laser engu-808 nm eduze kwe-infrared amasonto amane okwelashwa nge-transcranial okungathintani namagundane asebekhulile kanye ne-Alzheimer's. Lokhu kwelashwa kuthuthukise kakhulu ukusebenza kwamaseli e-endothelial lymphatic meningeal, kwathuthukisa ukuphuma kwe-lymphatic, futhi ekugcineni kwanciphisa izimpawu ze-pathological kanye nemisebenzi yokuqonda ethuthukisiwe kumagundane.
Ukukhuthaza Umsebenzi Wezinzwa Nge-Phototherapy
Ukwelashwa nge-phtotherapy kungathuthukisa futhi kuthuthukise ukusebenza kwe-neuronal ngezindlela ezahlukahlukene. Isibonelo, inqubo yokuzivikela komzimba idlala indima ebalulekile ku-Alzheimer's pathology. Izifundo zakamuva zibonisa ukuthi ukushiswa nge-laser eluhlaza engu-532 nm kungathuthukisa ukusebenza kweseli lomzimba, kubangele izindlela zangaphakathi kuma-neurons ajulile aphakathi, kuthuthukise i-vascular dementia, futhi kuthuthukise ukuguquguquka kokugeleza kwegazi kanye nezimpawu zomtholampilo ezigulini ze-Alzheimer's. Ukushiswa kwe-vascular kokuqala nge-laser eluhlaza kubonise ukuthuthuka okukhulu ekuqineni kwegazi, ekuqineni kwe-plasma, ekuhlanganisweni kwamaseli abomvu egazi, kanye nokuhlolwa kwengqondo.
Ukwelashwa kokukhanya okubomvu nokukhanya kwe-infrared (i-photobiomodulation) okusetshenziswa ezindaweni zomzimba ezingaphandle (emhlane nasemilenzeni) kungenza kusebenze amaseli omzimba noma izindlela zokuvikela zangaphakathi zamaseli okuqala, okufaka isandla ekusindeni kwe-neuronal kanye nokubonakaliswa kwezakhi zofuzo okuzuzisayo.
Umonakalo we-oxidative nawo uyinqubo ebalulekile ye-pathological ekuthuthukisweni kwe-Alzheimer's. Ucwaningo luphakamisa ukuthi ukushiswa kwemisebe yokukhanya okubomvu kungandisa umsebenzi we-ATP weseli, kubangele ushintsho lwe-metabolic kusuka ku-glycolysis kuya kumsebenzi we-mitochondrial kuma-microglia okuvuvukala athintekile yi-beta-amyloid ye-oligomeric, kuthuthukise amazinga e-microglia yokulwa nokuvuvukala, kuncishiswe ama-cytokine abangela ukuvuvukala, futhi kusebenze i-phagocytosis ukuvimbela ukufa kwe-neuronal.
Ukuthuthukisa ukuqaphela, ukuqwashisa, kanye nokunaka okuqhubekayo kungenye indlela esebenzayo yokuthuthukisa ikhwalithi yokuphila kweziguli ezine-Alzheimer's. Abacwaningi bathole ukuthi ukuchayeka ekukhanyeni okuluhlaza okwesibhakabhaka okufushane kuthinta kahle ukusebenza kwengqondo kanye nokulawulwa ngokomzwelo. Ukukhanya okuluhlaza okwesibhakabhaka kungakhuthaza umsebenzi wesekethe yezinzwa, kuthonye umsebenzi we-acetylcholinesterase (AchE) kanye ne-choline acetyltransferase (ChAT), ngaleyo ndlela kuthuthukise amakhono okufunda kanye nenkumbulo.
Imiphumela Emihle Ye-Phototherapy Kuma-Neuron Obuchopho
Ucwaningo olukhulayo olunegunya luqinisekisa imiphumela emihle ye-phototherapy ekusebenzeni kwezinzwa zobuchopho. Lusiza ekuvuseleleni izindlela zokuvikela zangaphakathi zamaseli omzimba, lukhuthaze ukubonakaliswa kwezakhi zofuzo zokusinda kwe-neuronal, futhi lulinganise amazinga ezinhlobo ze-oxygen ezisabelayo ze-mitochondrial. Lokhu okutholakele kusungula isisekelo esiqinile sezicelo zezokwelapha ze-phototherapy.
Ngokusekelwe kulokhu kuqonda, i-MERICAN Optical Energy Research Center, ngokubambisana nethimba laseJalimane kanye namanyuvesi amaningi, ucwaningo, kanye nezikhungo zezokwelapha, yenze ucwaningo oluhilela abantu abaneminyaka engu-30-70 abanokukhubazeka okuncane kokuqonda, ukwehla kwenkumbulo, ukuqonda okunciphile kanye nokwahlulela, kanye nekhono lokufunda elinciphile. Abahlanganyeli balandele iziqondiso zokudla kanye nendlela yokuphila enempilo ngenkathi bethola ukwelashwa nge-phototherapy ekamelweni lezempilo lase-MERICAN, ngezinhlobo zemithi ezihambisanayo kanye nemithamo.
Ngemva kwezinyanga ezintathu zokuhlolwa kwe-neuropsychological, ukuhlolwa kwesimo sengqondo, kanye nokuhlolwa kwengqondo, imiphumela ibonise ukuthuthuka okukhulu kumaphuzu e-MMSE, ADL, kanye ne-HDS phakathi kwabasebenzisi be-phototherapy ye-health cabin. Abahlanganyeli nabo babhekane nokunakwa okuthuthukisiwe kokubona, ikhwalithi yokulala, kanye nokukhathazeka okunciphile.
Lokhu okutholakele kusikisela ukuthi i-phototherapy ingasebenza njengokwelashwa okusekelayo ukulawula umsebenzi wamaseli obuchopho, ukunciphisa ukuvuvukala kwe-neuroinflammation kanye nezifo ezihlobene nayo, ukuthuthukisa ukuqonda, nokuthuthukisa inkumbulo. Ngaphezu kwalokho, kuvula izindlela ezintsha ze-phototherapy ukuze ziguqukele endleleni yokwelapha yokuvimbela.
