Isifo i-Alzheimer's, i-neurodeergenerative disorder eqhubekayo, ibonakala ngezimpawu ezinjengokulahlekelwa inkumbulo, i-aphasia, i-agnosia, kanye nokusebenza kabi kokuphatha. Ngokwesiko, iziguli ziye zathembela emithini ukuze zinciphise izimpawu. Kodwa-ke, ngenxa yokulinganiselwa kanye nemiphumela emibi engase ibe khona yalezi zidakamizwa, abacwaningi baphendule ukunaka kwabo kwe-phototherapy engahlaseli, befinyelela impumelelo ebalulekile eminyakeni yamuva.
Muva nje, ithimba eliholwa nguSolwazi Zhou Feifan wase-Biomedical Engineering College yase-Hainan University lithole ukuthi i-transcranial phototherapy engathinteki ingadambisa izimpawu ze-pathological futhi ithuthukise amakhono okuqonda kumagundane asebekhulile kanye ne-Alzheimer's. Lokhu okutholakele okuyisisekelo, okushicilelwe kumagazini i-Nature Communications, kunikeza isu elithembisayo lokulawula izifo ze-neurodegenerative.
Ukuqonda I-Alzheimer's Disease Pathology
Imbangela yangempela ye-Alzheimer's isalokhu ingacacile, kodwa ibonakala ngokuhlangana okungavamile kwamaprotheni e-beta-amyloid kanye nama-neurofibrillary tangles, okuholela ekungasebenzi kahle kwe-neuronal kanye nokuncipha kwengqondo. Ubuchopho, njengesitho somzimba esisebenza kakhulu ekusebenzeni kwe-metabolic, bukhiqiza udoti obalulekile we-metabolic ngesikhathi sokusebenza kwemizwa. Ukunqwabelana ngokweqile kwale mfucumfucu kungalimaza ama-neurons, kudinge ukususwa okuphumelelayo ngohlelo lwe-lymphatic.
Imikhumbi ye-meningeal lymphatic, ebaluleke kakhulu ekuthunjweni kwesistimu yezinzwa ephakathi, idlala indima ebalulekile ekuhlanzeni amaprotheni e-beta-amyloid anobuthi, imfucuza ye-metabolic, nokulawula umsebenzi wokuzivikela komzimba, okuwenza abe okuhloswe ngawo ukwelashwa.
I-Phototherapy's Impact ku-Alzheimer's
Ithimba likaSolwazi Zhou lisebenzise i-laser engu-808 nm eduze ne-infrared amasonto amane e-non-contact transcranial phototherapy kumagundane asebekhulile kanye ne-Alzheimer's. Lokhu kwelashwa kwathuthukisa kakhulu ukusebenza kwamaseli e-meningeal lymphatic endothelial, kwathuthukisa ukugeleza kwe-lymphatic, futhi ekugcineni kwadambisa izimpawu ze-pathological kanye nemisebenzi yokuqonda ethuthukisiwe kumagundane.
Ukukhuthaza Umsebenzi We-Neuronal nge-Phototherapy
I-Ptotherapy ingathuthukisa futhi ithuthukise ukusebenza kwe-neuronal ngokusebenzisa izindlela ezahlukahlukene. Isibonelo, inqubo yokuzivikela komzimba idlala indima ebalulekile ku-Alzheimer's pathology. Ucwaningo lwakamuva lubonisa ukuthi i-532 nm green laser irradiation ingakhuphula ukusebenza kwamangqamuzana omzimba omzimba, ivuse izindlela zangaphakathi kuma-neuron ajulile amaphakathi, ithuthukise ukuwohloka komqondo kwemithambo, futhi kuthuthukise ukugeleza kwegazi kanye nezimpawu zomtholampilo ezigulini ze-Alzheimer's. I-laser green vascular irradiation yokuqala ibonise ukuthuthuka okuphawulekayo ku-viscosity yegazi, i-plasma viscosity, ukuhlangana kwamangqamuzana egazi abomvu, nokuhlolwa kwe-neuropsychological.
Ukwelashwa kokukhanya okubomvu ne-infrared (i-photobiomodulation) esetshenziswa ezindaweni ezizungezile zomzimba (emuva nasemilenzeni) kungenza kusebenze amangqamuzana omzimba noma izindlela zokuzivikela ezingaphakathi kwamaseli e-stem, okunomthelela ekusindeni kwe-neuronal kanye nokuvezwa kofuzo okuzuzisayo.
Ukulimala kwe-oxidative nakho kuyinqubo ebalulekile ye-pathological ekuthuthukisweni kwe-Alzheimer's. Ucwaningo luphakamisa ukuthi ukukhanya okubomvu kungakhuphula umsebenzi we-ATP weselula, kubangele ukushintshwa kwe-metabolic kusuka ku-glycolysis kuye emsebenzini we-mitochondrial ku-microglia evuthayo ethintwa i-oligomeric beta-amyloid, ithuthukise amazinga e-microglia elwa nokuvuvukala, inciphise ama-cytokines avuvukalayo, futhi ivule i-phagocytosis ukuvimbela i-neuronal. ukufa.
Ukuthuthukisa ukuqapha, ukuqwashisa, nokunaka okuqhubekayo kungenye indlela esebenzayo yokuthuthukisa izinga lempilo leziguli ze-Alzheimer. Abacwaningi bathole ukuthi ukuchayeka ekukhanyeni okuluhlaza okwesibhakabhaka okufushane-wavelength kunomthelela omuhle ekusebenzeni kwengqondo nokulawula imizwa. I-blue light irradiation ingakhuthaza umsebenzi we-neural circuit, ithonye umsebenzi we-acetylcholinesterase (AchE) ne-choline acetyltransferase (Chat), ngaleyo ndlela ithuthukise amakhono okufunda nenkumbulo.
Imiphumela Emihle Ye-Phototherapy Kuma-Neurons Obuchopho
Indikimba ekhulayo yocwaningo olugunyaziwe iqinisekisa imiphumela emihle ye-phototherapy emsebenzini we-brain neuron. Isiza ukwenza kusebenze izindlela zokuvikela zangaphakathi zamangqamuzana omzimba, ikhuthaze ukubonakaliswa kofuzo kokusinda kwe-neuronal, futhi ilinganise amazinga ezinhlobo ze-oxygen esebenzayo ye-mitochondrial. Lokhu okutholakele kudala isisekelo esiqinile sezicelo zomtholampilo ze-phototherapy.
Ngokusekelwe kule mininingwane, i-MERICAN Optical Energy Research Center, ngokubambisana neqembu laseJalimane namanyuvesi amaningi, ucwaningo, nezikhungo zezokwelapha, yenze ucwaningo oluhilela abantu abaneminyaka engu-30-70 abanokukhubazeka okuncane kwengqondo, ukuncipha kwenkumbulo, ukuqonda okuncishisiwe nokwahlulela, kanye nekhono lokufunda elinciphile. Ababambiqhaza babambelele eziqondisweni zokudla kanye nendlela yokuphila enempilo ngenkathi belashwa ngezithombe kukhabhinethi yezempilo ye-MERICAN, enezinhlobo zemithi engaguquki nemithamo.
Ngemva kwezinyanga ezintathu zokuhlolwa kwe-neuropsychological, ukuhlolwa kwesimo sengqondo, nokuhlolwa kwengqondo, imiphumela yabonisa ukuthuthukiswa okuphawulekayo kumaphuzu we-MMSE, ADL, kanye ne-HDS phakathi kwabasebenzisi be-cabin phototherapy yezempilo. Abahlanganyeli baphinde bathola ukunakwa okuthuthukisiwe okubonakalayo, ikhwalithi yokulala, nokukhathazeka okuncishisiwe.
Lokhu okutholakele kusikisela ukuthi i-phototherapy ingase isebenze njengendlela yokwelapha esekelayo yokulawula ukusebenza kwamangqamuzana obuchopho, inciphise ukuvuvukala kwe-neuroinflammation nama-pathologies ahlobene, ithuthukise ukuqonda, futhi ithuthukise inkumbulo. Ngaphezu kwalokho, ivula izindlela ezintsha ze-phototherapy ukuze iguquke ibe yindlela yokwelapha yokuvimbela.
