Ukukhanya emaphethelweni abomvu naseduze kwe-infrared of spectrum kusheshisa ukuphulukiswa kuwo wonke amaseli nezicubu.Enye yezindlela abakufeza ngayo lokhu ukwenza njengama-antioxidants anamandla.Ziphinde zivimbele ukukhiqizwa kwe-nitric oxide.
Ingabe ukukhanya okubomvu nokuseduze kwe-infrared kungavimbela noma kuhlehlise ukulahlekelwa ukuzwa?
Ocwaningweni lwango-2016, abacwaningi basebenzise ukukhanya okuseduze kwe-infrared kumaseli azwayo ku-vitro ngaphambi kokuwafaka ngaphansi kwengcindezi ye-oxidative ngokuwachaya kobuthi obuhlukahlukene.Ngemva kokudalula amangqamuzana angaphambi kwe-conditioned kubuthi be-chemotherapy kanye ne-endotoxin, abacwaningi bocwaningo bathola ukuthi ukukhanya kuguqule imetabolism ye-mitochondrial kanye nokusabela kwengcindezi ye-oxidative kuze kufike emahoreni angu-24 ngemva kokwelashwa.
"Sibika ukwehla kwama-cytokines avuthayo kanye namazinga okucindezeleka okubangelwa yi-NIR esetshenziswe kumaseli wokuzwa we-HEI-OC1 ngaphambi kokwelashwa nge-gentamicin noma i-lipopolysaccharide," kubhala ababhali bocwaningo.
Imiphumela yocwaningo ibonise ukuthi ukwelashwa kwangaphambili ngokukhanya okuseduze kwe-infrared kunciphisa omaka be-pro-inflammatory abahlobene nokwanda kwezinhlobo ze-oxygen esebenzayo kanye ne-nitric oxide.
Isifundo #1: Ingabe Ukukhanya Okubomvu Kungakuhlehlisa Ukulahlekelwa Ukuzwa?
Umthelela wokukhanya okuseduze kwe-infrared ekulahlekelweni kokuzwa okulandela ubuthi be-chemotherapy uye wahlolwa.Ukuzwa kwahlolwa ngemva kokuphathwa kwe-gentamicin futhi futhi ngemva kwezinsuku eziyi-10 zokwelashwa okulula.
Lapho siskena izithombe ze-electron microscopic, “i-LLLT yenyuse kakhulu inani lamaseli ezinwele phakathi nokuphenduka okuyisisekelo.Ukuzwa kwathuthukiswa kakhulu nge-laser irradiation.Ngemuva kokwelashwa kwe-LLLT, kokubili umkhawulo wokuzwa kanye nokubalwa kwamaseli ezinwele kuye kwaba ngcono kakhulu. ”
Isifundo #2: Ingabe Ukukhanya Okubomvu Kungakuhlehlisa Ukulahlekelwa Ukuzwa?
Kulolu cwaningo, amagundane atholakale emsindweni omkhulu ezindlebeni zombili.Ngemuva kwalokho, izindlebe zabo zangakwesokudla zafakwa ukukhanya okuseduze kwe-infrared emizuzwini engama-30 yokwelashwa nsuku zonke izinsuku ezi-5.
Ukukalwa kwempendulo yobuchopho obuzwakalayo kwembule ukululama okusheshayo komsebenzi wokuzwa emaqenjini aphathwe nge-LLLT uma kuqhathaniswa neqembu elingabelaphi ezinsukwini ezi-2, 4, 7 kanye ne-14 ngemuva kokuchayeka komsindo.Ukuhlola i-morphological nakho kwembula izinga eliphezulu kakhulu lokusinda kwamangqamuzana ezinwele zezinwele emaqenjini e-LLLT.
Ibheka izinkomba zokucindezelwa kwe-oxidative kanye ne-apoptosis kumaseli angalashwanga nalashwa, abacwaningi bathola “Ukuzivikela okuqinile kubonwe ezicutshini zendlebe yangaphakathi yeqembu elingalashwa, kanti lezi zimpawu zehliswa eqenjini le-LLLT ngamandla ayi-165mW/cm(2) ukuminyana.”
"Okutholakele kwethu kusikisela ukuthi i-LLLT inemiphumela ye-cytoprotective ngokumelene ne-NIHL ngokuvinjwa kwenkulumo ye-iNOS kanye ne-apoptosis."
Isifundo #3: Ingabe Ukukhanya Okubomvu Kungakuhlehlisa Ukulahlekelwa Ukuzwa?
Ocwaningweni lwango-2012, amagundane ayisishiyagalolunye avezwa umsindo omkhulu futhi ukusetshenziswa kokukhanya okuseduze kwe-infrared ekutholeni ukuzwa kwahlolwa.Ngosuku olulandela ukuchayeka komsindo omkhulu, izindlebe zesokunxele zamagundane zaphathwa ngokukhanya okuseduze kwe-infrared imizuzu engama-60 izinsuku eziyi-12 zilandelana.Izindlebe ezifanele azizange ziphathwe futhi zibhekwa njengeqembu elilawulayo.
"Ngemuva kokukhanyiselwa kwe-12, umkhawulo wokuzwa wawuphansi kakhulu ezindlebeni zangakwesokunxele uma kuqhathaniswa nezindlebe zangakwesokudla."Uma kubhekwa kusetshenziswa isibonakhulu se-electron, inani lamaseli ezinwele ezizwakalayo ezindlebeni ezilashiwe lalilikhulu kakhulu kunalelo lezindlebe ezinganakiwe.
"Okutholakele kwethu kusikisela ukuthi i-laser irradiation esezingeni eliphansi ikhuthaza ukululama kokuzwa ngemuva kokuhlukumezeka okukhulu kwe-acoustic."
Isikhathi sokuthumela: Nov-21-2022